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Anaphase Topsy-Turvy : Cdk1 a securin, separase a CKI

Title data

Stemmann, Olaf ; Boos, Dominik ; Gorr, Ingo H.:
Anaphase Topsy-Turvy : Cdk1 a securin, separase a CKI.
In: Cell Cycle. Vol. 5 (January 2006) Issue 1 . - pp. 11-13.
ISSN 1551-4005
DOI: https://doi.org/10.4161/cc.5.1.2296

Official URL: Volltext

Abstract in another language

Chromosome segregation in mitosis and meiosis is triggered by activation of a large protease, separase. While it has been known for some time that the anaphase inhibitor securin regulates separase activity recent work shows that this is only half the story. In vertebrates Cdk1-dependent inhibition of separase represents a second, securin-independent branch of anaphase regulation. Furthermore, an unanticipated ability of separase to inhibit Cdk1 suggests additional, nonproteolytic functions of separase.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics > Chair Genetics - Univ.-Prof. Dr. Olaf Stemmann
Profile Fields > Advanced Fields > Molecular Biosciences
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 27 Mar 2015 07:16
Last Modified: 27 Mar 2015 07:16
URI: https://eref.uni-bayreuth.de/id/eprint/8552