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De Breuck, Jonas ; Jérôme, Valérie ; Freitag, Ruth ; Leiske, Meike N.:
Zwitterionic Amino-Acid-Derived Polyacrylamides with a Betaine Twist : Synthesis and Characterization.
In: Macromolecular Rapid Communications.
Bd. 46
(2025)
Heft 1
.
- 2400623.
ISSN 1521-3927
DOI: https://doi.org/10.1002/marc.202400623
Volltext
Angaben zu Projekten
| Projekttitel: |
Offizieller Projekttitel Projekt-ID Design optimierter aminosäurebasierter zwitterionischer Polymere mit zellulärer Spezifität 535904448 |
|---|---|
| Projektfinanzierung: |
Deutsche Forschungsgemeinschaft |
Abstract
Amino-acid-derived polyzwitterions and polybetaines (PBs) are two promising alternatives to non-ionic polymers, for example, to increase tumor permeability. In this study, amino-acid-derived polyzwitterions are synthesized and a strategy to quarternize the amine in the side chain functional group is developed to combine the advantages of both types. The functional monomer is polymerized via reversible addition−fragmentation chain-transfer polymerization for which a kinetic study is performed. Further, the impact of the permanent positive charge on amino-acid-derived polyzwitterions is studied based on two zwitterionic polymers obtained via post-polymerization modification (PPM) of Poly(N-acryloxysuccinimide) to allow good comparison between methylated and non-methylated polymers. Circular dichroism shows that the stereocenter remains intact during PPM. pH titration and ζ-potential measurements show that the methylated polymer has a negative ζ-potential over the measured pH range and, therefore, the polymer remains zwitterionic over a broader pH range than its non-methylated equivalent. Both polymers are well tolerated by mammalian cells up to concentrations of 1 mg mL−1. The study introduces a path to a new polymer class that combines the advantages of both PBs and amino-acid-derived polyzwitterions and highlights the impact a permanent charge has on the physiochemical properties.