Titelangaben
Jain, Aditi ; Margaliot, Michael ; Gupta, Arvind Kumar:
Large-scale mRNA translation and the intricate effects of competition for the finite pool of ribosomes.
In: Interface : Journal of the Royal Society.
Bd. 19
(2022)
Heft 188
.
- 20220033.
ISSN 1742-5662
DOI: https://doi.org/10.1098/rsif.2022.0033
Rez.: |
Angaben zu Projekten
Projektfinanzierung: |
Andere Israeli Science Foundation (ISF), Research grant DST-SERB, Government of India (grants CRG/2019/004669, MTR/2019/000312) |
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Abstract
We present a new theoretical framework for large-scale mRNA translation using a network of models called the ribosome flow model with Langmuir kinetics (RFMLK), interconnected via a pool of free ribosomes. The input to each RFMLK depends on the pool density, and it affects the initiation rate and potentially also the internal ribosome entry rates along each RFMLK. Ribosomes that detach from an RFMLK owing to termination or premature drop-off are fed back into the pool. We prove that the network always converges to a steady state, and study its sensitivity to variations in the parameters. For example, we show that if the drop-off rate at some site in some RFMLK is increased then the pool density increases and consequently the steady-state production rate in all the *other* RFMLKs increases. Surprisingly, we also show that modifying a parameter of a certain RFMLK can lead to arbitrary effects on the densities along the modified RFMLK, depending on the parameters in the entire network. We conclude that the competition for shared resources generates an indirect and intricate web of mutual effects between the mRNA molecules that must be accounted for in any analysis of translation.
Weitere Angaben
Publikationsform: | Artikel in einer Zeitschrift |
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Begutachteter Beitrag: | Ja |
Keywords: | mathematical modelling of competition for shared resources; ribosome drop-off; internal ribosome entry sites; cooperative dynamical systems; entrainment; context dependence in mRNA translation |
Institutionen der Universität: | Fakultäten > Fakultät für Mathematik, Physik und Informatik > Mathematisches Institut > Lehrstuhl Mathematik V (Angewandte Mathematik) Profilfelder > Advanced Fields > Nichtlineare Dynamik Forschungseinrichtungen > Zentrale wissenschaftliche Einrichtungen > Bayreuther Zentrum für Modellierung und Simulation (MODUS) |
Titel an der UBT entstanden: | Nein |
Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 510 Mathematik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
Eingestellt am: | 07 Mär 2025 11:14 |
Letzte Änderung: | 07 Mär 2025 11:14 |
URI: | https://eref.uni-bayreuth.de/id/eprint/92616 |