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Controllable cell adhesion, growth and orientation on layered silk protein films

Title data

Bauer, Felix ; Wohlrab, Stefanie ; Scheibel, Thomas:
Controllable cell adhesion, growth and orientation on layered silk protein films.
In: Biomaterials Science. Vol. 12 (1 December 2013) . - pp. 1244-1249.
ISSN 2047-4849
DOI: https://doi.org/10.1039/c3bm60114e

Official URL: Volltext

Abstract in another language

Due to their mechanical stability, biocompatibility and biodegradability, silks are promising materials for various biomedical applications including tissue engineering. Since the shape and the organisation of cells in and on scaffolds both affect their function, we tested patterned silk scaffolds made of three different silk proteins concerning their influence on cell adhesion, growth and orientation. Two different cell lines, BALB/3T3 fibroblasts and C2C12 myoblasts, showed controllable cell adhesion as well as orientation dependent on the silk proteins used and patterns made. Surprisingly, the presence of the integrin binding motif RGD did not influence cell adhesion and orientation on structured silk films, although it did so significantly on flat films.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: Der Artikel wurde zunächst online veröffentlicht am 29.07.2013
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 02 Apr 2015 05:33
Last Modified: 26 Nov 2015 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/9276