Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Oligomeric dual functional antibacterial polycaprolactone

Title data

Wang, Hui ; Synatschke, Christopher V. ; Raup, Alexander ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema:
Oligomeric dual functional antibacterial polycaprolactone.
In: Polymer Chemistry. Vol. 5 (2014) Issue 7 . - pp. 2453-2460.
ISSN 1759-9954
DOI: https://doi.org/10.1039/C3PY01467C

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Dual functional antibacterial and biodegradable caprolactone (CL) based oligomers were prepared by ring-opening polymerization of caprolactone using a polyguanidine macroinitiator. Primary amino (-NH2) end-groups of linear poly(hexamethylene guanidine) hydrochloride (PHMG) acted as initiating sites for caprolactone polymerization leading to block copolymers which combine the antibacterial properties of PHMG with degradability provided by PCL. The block structure of the material was confirmed with 2D NMR and MALDI-ToF-MS. Furthermore, the material exhibited temperature dependent solubility (upper critical solution temperature) in polar solvents such as methanol. The oligomers showed high antibacterial activity (reduction of bacterial cells was more than 3 orders of magnitude) even at short incubation times depending on the concentration and PHMG : PCL ratio while maintaining enzymatic degradability and biocompatibility.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: POLYMERIC SURFACE MODIFIERS; BIODEGRADABLE POLYMERS; OLIGOGUANIDINES; COATINGS
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 02 Apr 2015 11:34
Last Modified: 02 Apr 2015 11:34
URI: https://eref.uni-bayreuth.de/id/eprint/9589