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Effect of Guanidinylation on the Properties of Poly(2-aminoethylmethacrylate)-Based Antibacterial Materials

Title data

Mattheis, Claudia ; Wang, Hui ; Meister, Claus ; Agarwal, Seema:
Effect of Guanidinylation on the Properties of Poly(2-aminoethylmethacrylate)-Based Antibacterial Materials.
In: Macromolecular Bioscience. Vol. 13 (February 2013) Issue 2 . - pp. 242-255.
ISSN 1616-5187
DOI: https://doi.org/10.1002/mabi.201200217

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

The effect of converting ammonium into guanidine moieties, compared to other factors such as molecular weight or hydrophobicity, on the antibacterial activity is investigated for homo- and copolymers of 2-aminoethylmethacrylate in solution or coatings. Polymers are obtained by free radical polymerization, polymer-analogous guanidinylation is conducted with cyanamide; non-leaching immobilization is achieved by LBL assembly of homopolymers or crosslinking of functional sidegroups in copolymers. Antibacterial activity to Escherichia coli or Bacillus subtilis is determined by different standard methods. Guanidinylation improves antibacterial activity and speed as well as cytotoxicity of hydrophilic homo- and copolymers in solution or coatings.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: antibacterial materials; guanidine polymers; polyelectrolytes; quaternary ammonium polymers; structureproperty relations
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 01 Apr 2015 11:17
Last Modified: 01 Apr 2015 11:17
URI: https://eref.uni-bayreuth.de/id/eprint/9782