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Biocompatible and degradable poly(2-hydroxyethyl methacrylate) based polymers for biomedical applications

Title data

Zhang, Yi ; Chu, Dafeng ; Zheng, Mengyao ; Kissel, Thomas ; Agarwal, Seema:
Biocompatible and degradable poly(2-hydroxyethyl methacrylate) based polymers for biomedical applications.
In: Polymer Chemistry. Vol. 3 (2012) Issue 10 . - pp. 2752-2759.
ISSN 1759-9954
DOI: https://doi.org/10.1039/C2PY20403G

Official URL: Volltext

Abstract in another language

The present work provides a new, well characterized hydroxyl functionalized biocompatible and degradable polymer that could be suitable for many different biomedical applications. Poly(2-hydroxyethyl methacrylate) (PHEMA) is a widely used and researched biocompatible polymer, but lacks degradability. In this work, degradable and less toxic PHEMA with ester linkages in the backbone could be successfully made by radical copolymerization with cyclic ketene acetal. The protection-deprotection chemistry at the hydroxyl group of HEMA was necessary for the formation of targeted polymers. The structure of the resulting polymers was unambiguously proved by 2D NMR techniques. The polymers were significantly less toxic with cell viabilities of more than 80 even for very high polymer concentrations (100 mg mL-1). The polymers were hydrolytically degradable under basic conditions and also showed surface and bulk degradation using macrophages. We also demonstrated promising positive results for the use of such polymers as sustained drug delivery systems.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: POLYMERIZATION REACTIVITY RATIOS; TRANSFER RADICAL POLYMERIZATION; 2-HYDROXYETHYL METHACRYLATE; HYDROGELS; NANO
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 02 Apr 2015 11:42
Last Modified: 02 Apr 2015 11:42
URI: https://eref.uni-bayreuth.de/id/eprint/9797