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Synthetic Route and Characterization of Main Chain Ester-Containing Hydrolytically Degradable Poly(N,N-dimethylaminoethyl methacrylate)-Based Polycations

Title data

Agarwal, Seema ; Ren, Liqun ; Kissel, Thomas ; Bege, Nadja:
Synthetic Route and Characterization of Main Chain Ester-Containing Hydrolytically Degradable Poly(N,N-dimethylaminoethyl methacrylate)-Based Polycations.
In: Macromolecular Chemistry and Physics. Vol. 211 (15 April 2010) Issue 8 . - pp. 905-915.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.200900579

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

The possibility of introducing hydrolytically cleavable ester linkages onto the poly(N,N-dimethylaminoethyl methacrylate) for the formation of less toxic and degradable polycations is shown in this work. For achieving this aim, the copolymerization behavior of 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), with N,N-dimethylaminoethyl methacrylate (DMAEMA) is studied by free radical ring-opening polymerization. Structural characterization is performed using 1D and 2D NMR techniques. Under optimized reaction conditions, quantitative ring-opening of BMDO took place during the copolymerizations leading to the formation of poly(DMAEMA-co-ester)s. Blocky random copolymers were further quaternized by alkyl bromide to generate degradable cation containing polymers. Cytotoxicity results were highly encouraging and showed less cytotoxicity as compared to polyethyleneimine, which was used as a positive control. The formation and characterization of highly stable copolymer/DNA polyplexes is also shown here.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: cyclic ketene acetals; polycations; polyplex; radical polymerization; ring-opening polymerization
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 07 Apr 2015 12:56
Last Modified: 07 Apr 2015 12:56
URI: https://eref.uni-bayreuth.de/id/eprint/9885