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Synthetic Route and Characterization of Main Chain Ester-Containing Hydrolytically Degradable Poly(N,N-dimethylaminoethyl methacrylate)-Based Polycations

Titelangaben

Agarwal, Seema ; Ren, Liqun ; Kissel, Thomas ; Bege, Nadja:
Synthetic Route and Characterization of Main Chain Ester-Containing Hydrolytically Degradable Poly(N,N-dimethylaminoethyl methacrylate)-Based Polycations.
In: Macromolecular Chemistry and Physics. Bd. 211 (2010) Heft 8 . - S. 905-915.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.200900579

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Projektfinanzierung: Deutsche Forschungsgemeinschaft

Abstract

The possibility of introducing hydrolytically cleavable ester linkages onto the poly(N,N-dimethylaminoethyl methacrylate) for the formation of less toxic and degradable polycations is shown in this work. For achieving this aim, the copolymerization behavior of 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), with N,N-dimethylaminoethyl methacrylate (DMAEMA) is studied by free radical ring-opening polymerization. Structural characterization is performed using 1D and 2D NMR techniques. Under optimized reaction conditions, quantitative ring-opening of BMDO took place during the copolymerizations leading to the formation of poly(DMAEMA-co-ester)s. Blocky random copolymers were further quaternized by alkyl bromide to generate degradable cation containing polymers. Cytotoxicity results were highly encouraging and showed less cytotoxicity as compared to polyethyleneimine, which was used as a positive control. The formation and characterization of highly stable copolymer/DNA polyplexes is also shown here.

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Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: cyclic ketene acetals; polycations; polyplex; radical polymerization; ring-opening polymerization
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie II > Lehrstuhl Makromolekulare Chemie II - Univ.-Prof. Dr. Andreas Greiner
Profilfelder > Advanced Fields > Polymer- und Kolloidforschung
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Profilfelder
Profilfelder > Advanced Fields
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 07 Apr 2015 12:56
Letzte Änderung: 24 Feb 2022 14:31
URI: https://eref.uni-bayreuth.de/id/eprint/9885