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Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.

Title data

Lakshminarasimhan, Mahadevan ; Steegborn, Clemens:
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
In: Experimental Gerontology. Vol. 46 (2011) Issue 2-3 . - pp. 174-177.
ISSN 1873-6815
DOI: https://doi.org/10.1016/j.exger.2010.08.024

Abstract in another language

Advances in research on mitochondria have elucidated their importance in cell survival and cell death regulation in addition to their function in energy production. Mitochondria are further implicated in various metabolic and aging-related diseases, which are now assumed to be caused by misregulation of physiological systems rather than pure accumulation of oxidative damage. Thus, the signaling mechanisms within mitochondria and between the organelle and its environment have gained interest as potential drug targets. Emerging mitochondrial signaling systems with potential for exploiting them for therapeutic intervention include, among others, the NAD(+)-dependent protein deacetylases of the Sirtuin family, the redox enzyme p66(Shc), and enzymes of the cyclic adenosine monophosphate (cAMP) signaling pathways. Here, we discuss functions of these signaling systems in mitochondria, their roles in aging processes and disease, and their potential to serve as therapeutic targets.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 20849945
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 16 Apr 2015 13:02
Last Modified: 16 Apr 2015 13:02
URI: https://eref.uni-bayreuth.de/id/eprint/10374