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Interactions of cells with silk surfaces

Title data

Leal-Egaña, Aldo ; Scheibel, Thomas:
Interactions of cells with silk surfaces.
In: Journal of Materials Chemistry. Vol. 22 (2012) Issue 29 . - pp. 14330-14336.
ISSN 1364-5501

Official URL: Volltext

Abstract in another language

Polymers are often employed in tissue engineering to replace damaged extracellular matrix (ECM). During the last few decades silk proteins have been extensively investigated concerning their use as biopolymers for the generation of biocompatible, artificial scaffolds. Including the low or absence of immune-response and lack of cell toxicity, silk proteins present interesting properties useful for tissue engineering and organ repair. Since cell–matrix interactions define the behaviour of cells and posterior graft integration, this review is focused on the influence of surface properties of silk scaffolds
(wettability, charge, elasticity and biodegradability) on the biological activity (adhesion, proliferation and/or migration) of cells cultured thereon. Further, it is highlighted how the origin of silk proteins (natural source, regenerated or recombinantly produced), as well as the scaffold morphology and its treatment/post-treatment influence the scaffold surface properties in the context of biomedical applications.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 24 Jun 2015 07:35
Last Modified: 07 Jul 2022 12:58