The role of terminal domains during storage and assembly of spider silk proteins

Title data

Eisoldt, Lukas ; Thamm, Christopher ; Scheibel, Thomas:
The role of terminal domains during storage and assembly of spider silk proteins.
In: Biopolymers. Vol. 97 (2012) Issue 6 . - pp. 355-361.
ISSN 1097-0282
DOI: https://doi.org/10.1002/bip.22006

Official URL:

Abstract in another language

Fibrous proteins in nature fulfill a wide variety of functions in different structures ranging from cellular scaffolds to very resilient structures like tendons and even extra-corporal fibers such as silks in spider webs or silkworm cocoons. Despite their different origins and sequence varieties many of these fibrous proteins share a
common building principle: they consist of a large repetitive core domain flanked by relatively small nonrepetitive terminal domains. Amongst protein fibers, spider dragline silk shows prominent mechanical properties that exceed those of man-made fibers like Kevlar. Spider silk fibers assemble in a spinning process allowing the transformation from an aqueous solution into a solid fiber within milliseconds. Here, we highlight the role of the non-repetitive terminal domains of spider dragline silk proteins during storage in the gland and initiation of the fiber assembly process.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Additional notes:	In: Special Issues Silks
Keywords:	spider silk; biomaterials; silk assembly; nonrepetitive termini; fibrous proteins
Institutions of the University:	Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Biomaterials Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel Profile Fields > Advanced Fields > Advanced Materials Profile Fields > Advanced Fields > Molecular Biosciences Profile Fields > Advanced Fields > Polymer and Colloid Science Profile Fields > Emerging Fields > Food and Health Sciences Profile Fields Profile Fields > Advanced Fields Profile Fields > Emerging Fields
Result of work at the UBT:	Yes
DDC Subjects:	600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited:	24 Jun 2015 08:26
Last Modified:	25 Apr 2022 13:27
URI:	https://eref.uni-bayreuth.de/id/eprint/15376