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Control of Drug Loading and Release Properties of Spider Silk Sub-Microparticles

Title data

Blüm, Claudia ; Scheibel, Thomas:
Control of Drug Loading and Release Properties of Spider Silk Sub-Microparticles.
In: BioNanoScience. Vol. 2 (2012) Issue 2 . - pp. 67-74.
ISSN 2191-1649

Abstract in another language

The controlled delivery of water-soluble substances is one important issue in pharmaceutical and medical applications. Biocompatible polymers which can easily be processed in an all aqueous process with controllable and adjustable properties have been thoroughly investigated in the past for their use as drug delivery vehicles. Recently, we established sub-microparticles produced from the engineered spider silk protein eADF4(C16) as potential carriers for highly water-soluble drugs. Here, we investigate the influence of crosslinking on the structural integrity of the sub-microparticles and the effect on drug loading and release. To analyze the order-of-addition influences of processing of sub-microparticles on drug loading and release, we tested five different preparation routes. We showed that the preparation route largely influences the loading capacity of the eADF4(C16) submicroparticles.In the preferred preparation route, rhodamine B and the protein are co-precipitated by salting-out,yielding the highest loading. Further, crosslinking the proteins with APS (ammonium persulfate) and Rubpy (Tris(2,2′- bipyridyl)dichlororuthenium(II)) has an impact on loading as well as on the release behavior of drug molecules as shown exemplarily with rhodamine B.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: Artikel erschien zunächst online am 02.02.2012
Keywords: Drug delivery; Crosslinking; Recombinant spider silk protein; Particles
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 08 Oct 2015 13:19
Last Modified: 26 Nov 2015 10:51