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Formulation of poorly water-soluble substances using self-assembling spider silk protein

Title data

Liebmann, Burkhard ; Hümmerich, Daniel ; Scheibel, Thomas ; Fehr, Marcus:
Formulation of poorly water-soluble substances using self-assembling spider silk protein.
In: Colloids and Surfaces A : Physicochemical and Engineering Aspects. Vol. 331 (2008) Issue 1-2 . - pp. 126-132.
ISSN 1873-4359

Abstract in another language

In nature self-assembly of soluble monomeric proteins to defined supramolecular structures is an essential
process in the formation of morphologically distinct biological materials like cells, tissues, diatoms or
mollusk shells. Using these proteins, complex structures in the nanometer and micrometer scale can be
generated that are hardly obtainable by other methods. The engineered ADF4(C16) spider silk protein
is mimicking the sequence of the dragline silk protein ADF4 of the spider Araneus diadematus and can
be synthesized by a biotechnological production process using Escherichia coli (E. coli) as host organism.
From the soluble ADF4(C16) monomers assembly of nanofibers, microbeads and films is possible. The
purified monomeric ADF4(C16) strongly interacts with hydrophobic surfaces and particles of poorlywatersoluble
substances. Based on this effect ADF4(C16) could be used for colloidal stabilization of hydrophobic
particles in aqueous environment. Poorlywater-soluble substances can also be encapsulated in ADF4(C16)
microbeads during self-assembly. The release of the encapsulated ingredientswas induced by proteolytic
cleavage of the microbead structure. These results show that ADF4(C16) protein microbeads have a high
potential as a storage and delivery systemfor poorlywater-soluble active ingredients in several application
fields like cosmetics, pharma or nutrition.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Spider silk protein; Microbeads; Formulation; Encapsulation; Drug delivery
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 23 Sep 2015 12:19
Last Modified: 14 Feb 2023 12:23