at Google ScholarTitle data
Buchner, Johannes ; Scheibel, Thomas:
Protein Aggregation as a Cause for Disease.
In: Starke, Br. K. ; Gaestel, Matthias
(ed.):
Molecular chaperones in Health and Disease. -
Berlin
: Springer
,
2006
. - pp. 199-219
. - (Handbook of Experimental Pharmacology
; 172
)
ISBN 978-3-540-25875-9
DOI: https://doi.org/10.1007/3-540-29717-0_9
Abstract in another language
The ability of proteins to fold into a defined and functional conformation is one of the most fundamental processes in biology. Certain conditions, however, initiate misfolding or unfolding of proteins. This leads to the loss of functional protein or it can result in a wide range of diseases. One group of diseases, which includes Alzheimer’s, Parkinson’s, Huntington’s disease, and the transmissible spongiformencephalopathies (prion diseases),
involves deposition of aggregated proteins. Normally, such protein aggregates are not found in properly functioning biological systems, because a variety of mechanisms inhibit their formation. Understanding the nature of these protective mechanisms together with the understanding of factors reducing or deactivating the natural protection machinery will be crucial for developing strategies to prevent and treat these disastrous diseases.
Further data
| Item Type: | Article in a book |
|---|---|
| Refereed: | Yes |
| Keywords: | Alzheimer; Amyloid; Huntington; Parkinson; Prion; Protein deposits;Quality control; Toxic species |
| Institutions of the University: | Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Biomaterials Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel Profile Fields > Advanced Fields > Advanced Materials Profile Fields > Advanced Fields > Molecular Biosciences Profile Fields > Advanced Fields > Polymer and Colloid Science Profile Fields > Emerging Fields > Food and Health Sciences Profile Fields Profile Fields > Advanced Fields Profile Fields > Emerging Fields |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 620 Engineering |
| Date Deposited: | 13 Oct 2015 10:08 |
| Last Modified: | 26 Nov 2015 10:51 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/20330 |