Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and Optical Imaging

Title data

Müllner, Markus ; Schallon, Anja ; Walther, Andreas ; Freitag, Ruth ; Müller, Axel H. E.:
Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and Optical Imaging.
In: Biomacromolecules. Vol. 11 (2010) Issue 2 . - pp. 390-396.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm901099p

Official URL:

Abstract in another language

We report a general and facile approach for the fabrication of a new class of near monodisperse hybrid nanoparticles via RAFT polymerization and self-assembly in water. Furthermore, we combine a fluorescent inorganic silica core with a biocompatible polymer shell and a terminal unit susceptible to facile conjugations via click chemistry. A tailoring of the weight fractions of both components allows a tuning of the size of the formed aggregates. Fluorescent properties and the crosslinking into an organic-inorganic hybrid network are realized by copolymerizing a dye-functionalized monomer 1-pyrenebutyl acrylate and a trimethoxysilane-carrying one, (3-acryloxypropyl)trimethoxysilane. The potential of these stabilized and fluorescent nanoparticles as biocompatible carriers for intracellular delivery is demonstrated via in vitro experiments on lung cancer cells.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Additional notes:	PMID: 20025293
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Process Biotechnology Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag Faculties
Result of work at the UBT:	Yes
DDC Subjects:	600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 610 Medicine and health 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited:	24 Feb 2016 13:13
Last Modified:	24 Feb 2016 13:13
URI:	https://eref.uni-bayreuth.de/id/eprint/31029