Cloning of Chicken hsp90β : The Only Vertebrate hsp90 Insensitive to Heat Shock

Titelangaben

Meng, X. ; Jérôme, Valérie ; Devin, Jocelyne ; Baulieu, Etienne-Emile ; Catelli, Maria-Grazia:
Cloning of Chicken hsp90β : The Only Vertebrate hsp90 Insensitive to Heat Shock.
In: Biochemical and Biophysical Research Communications. Bd. 190 (1993) Heft 2 . - S. 630-636.
ISSN 1090-2104
DOI: https://doi.org/10.1006/bbrc.1993.1095

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Abstract

The cloning of chicken hsp90β, reported here, supports the hypothesis that the hsp90α and β genes are the result of a gene duplication event that occured at the time of the emergence of vertebrates. Avian hsp90β mRNA is not inducible by thermal stress contrary to the mouse and human hsp90α and β mRNAs. Moreover, hsp90β mRNA level is not increased by mitogenic stimuli, like serum or insulin, which induce hsp90α mRNA. Different functions and regulations of hsp90α and β will be probably more easily understood in the avian species than in higher vertebrates.