at Google ScholarTitle data
Cramer, Patrick ; Armache, Karim J. ; Baumli, Sonja ; Benkert, Stefan ; Brueckner, Florian ; Buchen, Claudia ; Damsma, Gerke E. ; Dengl, Stefan ; Geiger, Sebastian R. ; Jasiak, Anja J. ; Jawhari, Anass ; Jennebach, Stefan ; Kamenski, Tomislav ; Kettenberger, Hubert ; Kuhn, Claus-D. ; Lehmann, Elisabeth ; Leike, Kristin ; Sydow, Jasmin F. ; Vannini, Alessandro:
Structure of eukaryotic RNA polymerases.
In: Annual Review of Biophysics.
Vol. 37
(2008)
.
- pp. 337-352.
ISSN 1936-122X
DOI: https://doi.org/10.1146/annurev.biophys.37.032807.130008
Abstract in another language
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of the transcription mechanism, including initiation at promoter DNA, elongation of the mRNA chain, tunability of the polymerase active site, which supports RNA synthesis and cleavage, and the response of Pol II to DNA lesions. Detailed structural studies of Pol I and Pol III were reported recently and showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | Animals; *DNA-Directed RNA Polymerases/chemistry/genetics/ultrastructure; Enzyme Activation; Humans; *Models, Chemical; *Models, Genetic; Models, Molecular; RNA/*biosynthesis/*chemistry/genetics; Transcription, Genetic/*genetics |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Profile Fields > Advanced Fields > Molecular Biosciences Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Profile Fields Profile Fields > Advanced Fields Research Institutions Research Institutions > Research Centres |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 570 Life sciences, biology |
| Date Deposited: | 10 Jan 2017 11:07 |
| Last Modified: | 10 Jan 2017 11:07 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/35640 |