at Google ScholarTitle data
Feldmeier, Kaspar ; Höcker, Birte:
Computational protein design of ligand binding and catalysis.
In: Current Opinion in Chemical Biology.
Vol. 17
(2013)
Issue 6
.
- pp. 929-933.
ISSN 1879-0402
DOI: https://doi.org/10.1016/j.cbpa.2013.10.002
Abstract in another language
The vision of custom-made proteins by computation appears closer than ever. Computational methods have advanced rapidly in recent years and proteins have been designed to catalyze new reactions. A number of second-generation enzyme designs analyzed possible bottlenecks and started tackling emergent problems. Detailed experimental analysis combined with structure determination and molecular dynamics simulations as well as design optimization with directed evolution techniques have led to important insights. While ligand recognition seems to be particularly problematic, new approaches focus on this design aspect and promising improvements have been made.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Birte Höcker Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 01 Jun 2017 08:33 |
| Last Modified: | 27 Oct 2022 10:35 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/37227 |