at Google ScholarTitle data
Höcker, Birte:
Engineering chimaeric proteins from fold fragments : "hopeful monsters" in protein design.
In: Biochemical Society Transactions.
Vol. 41
(2013)
Issue 5
.
- pp. 1137-1140.
ISSN 1470-8752
DOI: https://doi.org/10.1042/BST20130099
Abstract in another language
Modern highly complex proteins evolved from much simpler and less specialized subunits. The same concept can be applied in protein engineering to construct new well-folded proteins. Hybrid proteins or chimaeras can be built from contemporary protein fragments through illegitimate recombination. Even parts from different globular folds can be fitted together using rational design methodologies. Furthermore, intrinsic functional properties encoded in the fold fragments allow rapid adaptation of the new proteins and thus provide interesting starting scaffolds for further redesign.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Birte Höcker Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 01 Jun 2017 08:38 |
| Last Modified: | 20 Apr 2022 11:01 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/37228 |