at Google ScholarTitle data
Faltz, Heike ; Bender, Christoph ; Wöhrl, Birgitta M. ; Vogel‐Bachmayr, Karin ; Hübscher, Ullrich ; Ramadan, Kristijan ; Liebscher, Jürgen:
Double Cyclization of Bis(α‐hetarylmethyl)amino Esters to Optically Active Bridged N‐Heterocycles of HIV‐Inhibiting Activitv.
In: European Journal of Organic Chemistry.
(2004)
Issue 16
.
- pp. 3484-3496.
ISSN 1099-0690
DOI: https://doi.org/10.1002/ejoc.200400136
Abstract in another language
Anellated 1‐azabicyclo[3.3.1]nonanes 6 were synthesized by several routes starting from natural α‐amino esters 2 and o‐haloaryl‐ or o‐bromohetarylmethyl bromides 1. N‐Alkylation of the starting amino esters to 5 and 3 was followed by halogen/lithium exchange and double cyclization. The cyclization products 6 exhibit interesting inhibition of RNase H and DNA‐polymerase activity of reverse transcriptase (RT) of HIV‐1 at concentrations where human cellular DNA polymerases are not affected.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry with an Emphasis on Biophysical Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Apl. Prof. Dr. Birgitta Wöhrl Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 500 Science > 540 Chemistry 500 Science > 570 Life sciences, biology |
| Date Deposited: | 17 May 2019 06:20 |
| Last Modified: | 23 Aug 2022 06:45 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/48955 |