bei Google ScholarTitelangaben
Eckstein, Max L. ; Farinha, Juliano Boufleur ; McCarthy, Olivia ; West, Daniel J. ; Yardley, Jane E. ; Bally, Lia ; Zueger, Thomas ; Stettler, Christoph ; Boff, Winston ; Reischak-Oliveira, Alvaro ; Riddell, Michael C. ; Zaharieva, Dessi P. ; Pieber, Thomas R. ; Müller, Alexander ; Birnbaumer, Philipp ; Aziz, Faisal ; Brugnara, Laura ; Haahr, Hanne L. ; Zijlstra, Eric ; Heise, Tim ; Sourij, Harald ; Roden, Michael ; Hofmann, Peter ; Bracken, Richard M. ; Pesta, Dominik ; Moser, Othmar:
Differences in Physiological Responses to Cardiopulmonary Exercise Testing in Adults With and Without Type 1 Diabetes : A Pooled Analysis.
In: Diabetes Care.
Bd. 44
(2021)
Heft 1
.
- S. 240-247.
ISSN 0149-5992
DOI: https://doi.org/10.2337/dc20-1496
Abstract
OBJECTIVE To investigate physiological responses to cardiopulmonary exercise (CPX) testing in adults with type 1 diabetes compared with age-, sex-, and BMI-matched control participants without type 1 diabetes. RESEARCH DESIGN AND METHODS We compared results from CPX tests on a cycle ergometer in individuals with type 1 diabetes and control participants without type 1 diabetes. Parameters were peak and threshold variables of VO2, heart rate, and power output. Differences between groups were investigated through restricted maximum likelihood modeling and post hoc tests. Differences between groups were explained by stepwise linear regressions (P < 0.05). RESULTS Among 303 individuals with type 1 diabetes (age 33 [interquartile range 22; 43] years, 93 females, BMI 23.6 [22; 26] kg/m2, HbA1c 6.9% [6.2; 7.7%] [52 (44; 61) mmol/mol]), VO2peak (32.55 [26.49; 38.72] vs. 42.67 ± 10.44 mL/kg/min), peak heart rate (179 [170; 187] vs. 184 [175; 191] beats/min), and peak power (216 [171; 253] vs. 245 [200; 300] W) were lower compared with 308 control participants without type 1 diabetes (all P < 0.001). Individuals with type 1 diabetes displayed an impaired degree and direction of the heart rate-to-performance curve compared with control participants without type 1 diabetes (0.07 [−0.75; 1.09] vs. 0.66 [−0.28; 1.45]; P < 0.001). None of the exercise physiological responses were associated with HbA1c in individuals with type 1 diabetes. CONCLUSIONS Individuals with type 1 diabetes show altered responses to CPX testing, which cannot be explained by HbA1c. Intriguingly, the participants in our cohort were people with recent-onset type 1 diabetes; heart rate dynamics were altered during CPX testing.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Lehrstuhl Exercise Physiology > Lehrstuhl Exercise Physiology - Univ.-Prof. Dr. Othmar Moser Fakultäten Fakultäten > Kulturwissenschaftliche Fakultät Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Lehrstuhl Exercise Physiology |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| Eingestellt am: | 30 Nov 2020 11:15 |
| Letzte Änderung: | 17 Feb 2022 11:35 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/60526 |