at Google ScholarTitle data
Eckstein, Max L. ; Farinha, Juliano Boufleur ; McCarthy, Olivia ; West, Daniel J. ; Yardley, Jane E. ; Bally, Lia ; Zueger, Thomas ; Stettler, Christoph ; Boff, Winston ; Reischak-Oliveira, Alvaro ; Riddell, Michael C. ; Zaharieva, Dessi P. ; Pieber, Thomas R. ; Müller, Alexander ; Birnbaumer, Philipp ; Aziz, Faisal ; Brugnara, Laura ; Haahr, Hanne L. ; Zijlstra, Eric ; Heise, Tim ; Sourij, Harald ; Roden, Michael ; Hofmann, Peter ; Bracken, Richard M. ; Pesta, Dominik ; Moser, Othmar:
Differences in Physiological Responses to Cardiopulmonary Exercise Testing in Adults With and Without Type 1 Diabetes : A Pooled Analysis.
In: Diabetes Care.
Vol. 44
(2021)
Issue 1
.
- pp. 240-247.
ISSN 0149-5992
DOI: https://doi.org/10.2337/dc20-1496
Abstract in another language
OBJECTIVE To investigate physiological responses to cardiopulmonary exercise (CPX) testing in adults with type 1 diabetes compared with age-, sex-, and BMI-matched control participants without type 1 diabetes. RESEARCH DESIGN AND METHODS We compared results from CPX tests on a cycle ergometer in individuals with type 1 diabetes and control participants without type 1 diabetes. Parameters were peak and threshold variables of VO2, heart rate, and power output. Differences between groups were investigated through restricted maximum likelihood modeling and post hoc tests. Differences between groups were explained by stepwise linear regressions (P < 0.05). RESULTS Among 303 individuals with type 1 diabetes (age 33 [interquartile range 22; 43] years, 93 females, BMI 23.6 [22; 26] kg/m2, HbA1c 6.9% [6.2; 7.7%] [52 (44; 61) mmol/mol]), VO2peak (32.55 [26.49; 38.72] vs. 42.67 ± 10.44 mL/kg/min), peak heart rate (179 [170; 187] vs. 184 [175; 191] beats/min), and peak power (216 [171; 253] vs. 245 [200; 300] W) were lower compared with 308 control participants without type 1 diabetes (all P < 0.001). Individuals with type 1 diabetes displayed an impaired degree and direction of the heart rate-to-performance curve compared with control participants without type 1 diabetes (0.07 [−0.75; 1.09] vs. 0.66 [−0.28; 1.45]; P < 0.001). None of the exercise physiological responses were associated with HbA1c in individuals with type 1 diabetes. CONCLUSIONS Individuals with type 1 diabetes show altered responses to CPX testing, which cannot be explained by HbA1c. Intriguingly, the participants in our cohort were people with recent-onset type 1 diabetes; heart rate dynamics were altered during CPX testing.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology > Chair Exercise Physiology - Univ.-Prof. Dr. Othmar Moser Faculties Faculties > Faculty of Cultural Studies Faculties > Faculty of Cultural Studies > Department of Sport Science Faculties > Faculty of Cultural Studies > Department of Sport Science > Chair Exercise Physiology |
| Result of work at the UBT: | Yes |
| DDC Subjects: | 600 Technology, medicine, applied sciences > 610 Medicine and health |
| Date Deposited: | 30 Nov 2020 11:15 |
| Last Modified: | 17 Feb 2022 11:35 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/60526 |