at Google ScholarTitle data
Romero-Romero, Sergio ; Kordes, Sina ; Michel, Florian ; Höcker, Birte:
Evolution, folding, and design of TIM barrels and related proteins.
In: Current Opinion in Structural Biology.
Vol. 68
(2021)
.
- pp. 94-104.
ISSN 0959-440X
DOI: https://doi.org/10.1016/j.sbi.2020.12.007
Project information
| Project title: |
Project's official title Project's id Protein Lego - Protein design from sub-domain sized fragments 647548 |
|---|---|
| Project financing: |
Alexander von Humboldt-Stiftung VolkswagenStiftung European Research Council |
Abstract in another language
Proteins are chief actors in life that perform a myriad of exquisite functions. This diversity has been enabled through the evolution and diversification of protein folds. Analysis of sequences and structures strongly suggest that numerous protein pieces have been reused as building blocks and propagated to many modern folds. This information can be traced to understand how the protein world has diversified. In this review, we discuss the latest advances in the analysis of protein evolutionary units, and we use as a model system one of the most abundant and versatile topologies, the TIM-barrel fold, to highlight the existing common principles that interconnect protein evolution, structure, folding, function, and design.