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On-demand male contraception via acute inhibition of soluble adenylyl cyclase

Title data

Balbach, Melanie ; Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Ritagliati, Carla ; Myers, Robert W. ; Huggins, David J. ; Steegborn, Clemens ; Miranda, Ileana C. ; Meinke, Peter T. ; Buck, Jochen ; Levin, Lonny R.:
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
In: Nature Communications. Vol. 14 (2023) Issue 1 . - 637.
ISSN 2041-1723

Abstract in another language

Nearly half of all pregnancies are unintended; thus, existing family planning options are inadequate. For men, the only choices are condoms and vasectomy, and most current efforts to develop new contraceptives for men impact sperm development, meaning that contraception requires months of continuous pretreatment. Here, we provide proof-of-concept for an innovative strategy for on-demand contraception, where a man would take a birth control pill shortly before sex, only as needed. Soluble adenylyl cyclase (sAC) is essential for sperm motility and maturation. We show a single dose of a safe, acutely-acting sAC inhibitor with long residence time renders male mice temporarily infertile. Mice exhibit normal mating behavior, and full fertility returns the next day. These studies define sAC inhibitors as leads for on-demand contraceptives for men, and they provide in vivo proof-of-concept for previously untested paradigms in contraception; on-demand contraception after just a single dose and pharmacological contraception for men.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 27 Feb 2023 08:06
Last Modified: 27 Feb 2023 08:06