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Mohamed, Mohamed Alaa ; Fallahi, Afsoon ; El-Sokkary, Ahmed M. A. ; Salehi, Sahar ; Akl, Magda A. ; Jafari, Amin ; Tamayol, Ali ; Fenniri, Hicham ; Khademhosseini, Ali ; Andreadis, Stelios T. ; Cheng, Chong:
Stimuli-responsive hydrogels for manipulation of cell microenvironment : From chemistry to biofabrication technology.
In: Progress in Polymer Science.
Bd. 98
(2019)
.
- 101147.
ISSN 0079-6700
DOI: https://doi.org/10.1016/j.progpolymsci.2019.101147
Abstract
Native tissues orchestrate their functions by complex interdependent cascades of biochemical and biophysical cues that vary spatially and temporally during cellular processes. Scaffolds with well-tuned structural, mechanical, and biochemical properties have been developed to guide cell behavior and provide insight on cell-matrix interaction. However, static scaffolds very often fail to mimic the dynamicity of native extracellular matrices. Stimuli-responsive scaffolds have emerged as powerful platforms that capture vital features of native tissues owing to their ability to change chemical and physical properties in response to cytocompatible stimuli, thus enabling on-demand manipulation of cell microenvironment. The vast expansion in biorthogonal chemistries and stimuli-responsive functionalities has fuelled further the development of new smart scaffolds that can permit multiple irreversible or reversible spatiotemporal modulation of cell-directing cues, thereby prompting in-depth studies to interpret the decisive elements that regulate cell behavior. Integration of stimuli-responsive hydrogels with current biofabrication technologies has allowed the development of dynamic scaffolds with organizational features and hierarchical architectures similar to native tissues. This review highlights the progress achieved using stimuli-responsive hydrogels in fundamental cell biology studies, with particular emphasis on the interplay between chemistry, biomaterials design, and biofabrication technologies for manipulation of cell microenvironment.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | Stimuli-responsive hydrogels; Cellular microenvironment; Cell-biomaterial interaction; Spatiotemporal modulation; Dynamic biomaterials; Biofabrication technology |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien > Lehrstuhl Biomaterialien - Univ.-Prof. Dr. Thomas Scheibel |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 08 Mär 2023 13:33 |
| Letzte Änderung: | 08 Mär 2023 13:33 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/74133 |