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Generation of PGS/PCL Blend Nanofibrous Scaffolds Mimicking Corneal Stroma Structure

Titelangaben

Salehi, Sahar ; Fathi, Mohammadhossein ; Javanmard, Shaghayegh Haghjooy ; Bahners, Thomas ; Gutmann, Jochen S. ; Ergün, Süleyman ; Steuhl, Klaus P. ; Fuchsluger, Thomas A.:
Generation of PGS/PCL Blend Nanofibrous Scaffolds Mimicking Corneal Stroma Structure.
In: Macromolecular Materials and Engineering. Bd. 299 (2014) Heft 4 . - S. 455-469.
ISSN 1439-2054
DOI: https://doi.org/10.1002/mame.201300187

Abstract

Morphological studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(ϵ-caprolactone)(PCL) blends for application as corneal tissue scaffolds are presented. Parallel conductive bars are used as ground electrode to generate unidirectional nanofibers. Scaffolds have fibers diameter in the range of 550–300 nm. The structural stability and wettability, especially the in vitro degradation rate, of the electrospun scaffolds can be controlled by regulating the blended ratio of the polymers. The results indicate that PGS/PCL nanofiber scaffolds can be considered as ideal candidates for corneal tissue engineering scaffolds. The particular motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of the cornea.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien
Titel an der UBT entstanden: Nein
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Eingestellt am: 13 Mär 2023 12:30
Letzte Änderung: 13 Mär 2023 12:30
URI: https://eref.uni-bayreuth.de/id/eprint/74214