bei Google ScholarTitelangaben
Liu, Yang ; Medda, Rebecca ; Liu, Zheng ; Galior, Kornelia ; Yehl, Kevin ; Spatz, Joachim P. ; Cavalcanti-Adam, Elisabetta Ada ; Salaita, Khalid:
Nanoparticle tension probes patterned at the nanoscale : impact of integrin clustering on force transmission.
In: Nano Letters.
Bd. 14
(2014)
Heft 10
.
- S. 5539-5546.
ISSN 1530-6992
DOI: https://doi.org/10.1021/nl501912g
Abstract
Herein we aimed to understand how nanoscale clustering of RGD ligands alters the mechano-regulation of their integrin receptors. We combined molecular tension fluorescence microscopy with block copolymer micelle nanolithography to fabricate substrates with arrays of precisely spaced probes that can generate a 10-fold fluorescence response to pN-forces. We found that the mechanism of sensing ligand spacing is force-mediated. This strategy is broadly applicable to investigating receptor clustering and its role in mechanotransduction pathways.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | Nanopatterning; receptor clustering; molecular tension fluorescence microscopy ; focal adhesion; mechanotransduction; integrin |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 12 Jun 2023 12:51 |
| Letzte Änderung: | 12 Jun 2023 12:51 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81168 |