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Challenges in imaging cell surface receptor clusters

Title data

Medda, Rebecca ; Giske, Arnold ; Cavalcanti-Adam, Elisabetta Ada:
Challenges in imaging cell surface receptor clusters.
In: Optics and Lasers in Engineering. Vol. 76 (2016) . - pp. 3-8.
ISSN 1873-0302

Abstract in another language

Super-resolution microscopy offers unique tools for visualizing and resolving cellular structures at the molecular level. STED microscopy is a purely optical method where neither complex sample preparation nor mathematical post-processing is required. Here we present the use of STED microscopy for imaging receptor cluster composition. We use two-color STED to further determine the distribution of two different receptor subunits of the family of receptor serine/threonine kinases in the presence or absence of their ligands. The implications of receptor clustering on the downstream signaling are discussed, and future challenges are also presented.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: BMP receptors; STED microscopy; Super-resolution microscopy; Fluorescence microscopy
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Result of work at the UBT: No
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 12 Jun 2023 11:32
Last Modified: 12 Jun 2023 11:32