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Palamidessi, Andrea ; Malinverno, Chiara ; Frittoli, Emanuela ; Corallino, Salvatore ; Barbieri, Elisa ; Sigismund, Sara ; Beznoussenko, Galina V. ; Martini, Emanuele ; Garre, Massimiliano ; Ferrara, Ines ; Tripodo, Claudio ; Ascione, Flora ; Cavalcanti-Adam, Elisabetta Ada ; Li, Qingsen ; Di Fiore, Pier Paolo ; Parazzoli, Dario ; Giavazzi, Fabio ; Cerbino, Roberto ; Scita, Giorgio:
Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.
In: Nature Materials.
Bd. 18
(2019)
Heft 11
.
- S. 1252-1263.
ISSN 1476-4660
DOI: https://doi.org/10.1038/s41563-019-0425-1
Abstract
During wound repair, branching morphogenesis and carcinoma dissemination, cellular rearrangements are fostered by a solid-to-liquid transition, known as unjamming. The biomolecular machinery behind unjamming and its pathophysiological relevance remain, however, unclear. Here, we study unjamming in a variety of normal and tumorigenic epithelial two-dimensional (2D) and 3D collectives. Biologically, the increased level of the small GTPase RAB5A sparks unjamming by promoting non-clathrin-dependent internalization of epidermal growth factor receptor that leads to hyperactivation of the kinase ERK1/2 and phosphorylation of the actin nucleator WAVE2. This cascade triggers collective motility effects with striking biophysical consequences. Specifically, unjamming in tumour spheroids is accompanied by persistent and coordinated rotations that progressively remodel the extracellular matrix, while simultaneously fluidizing cells at the periphery. This concurrent action results in collective invasion, supporting the concept that the endo-ERK1/2 pathway is a physicochemical switch to initiate collective invasion and dissemination of otherwise jammed carcinoma.
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| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 07 Jun 2023 12:28 |
| Letzte Änderung: | 07 Jun 2023 12:28 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81207 |