bei Google ScholarTitelangaben
Yu, Leixiao ; Hou, Yong ; Xie, Wenyan ; Camacho, Jose Luis Cuellar ; Cheng, Chong ; Holle, Andrew ; Young, Jennifer ; Trappmann, Britta ; Zhao, Weifeng ; Melzig, Matthias F. ; Cavalcanti-Adam, Elisabetta Ada ; Zhao, Changsheng ; Spatz, Joachim P. ; Wei, Qiang ; Haag, Rainer:
Ligand diffusion enables force‐independent cell adhesion via activating α5β1 integrin and initiating rac and RhoA signaling.
In: Advanced Materials.
Bd. 32
(2020)
Heft 29
.
- 2002566.
ISSN 1521-4095
DOI: https://doi.org/10.1002/adma.202002566
Abstract
Cells reside in a dynamic microenvironment in which adhesive ligand availability, density, and diffusivity are key factors regulating cellular behavior. Here, the cellular response to integrin-binding ligand dynamics by directly controlling ligand diffusivity via tunable ligand–surface interactions is investigated. Interestingly, cell spread on the surfaces with fast ligand diffusion is independent of myosin-based force generation. Fast ligand diffusion enhances α5β1 but not αvβ3 integrin activation and initiates Rac and RhoA but not ROCK signaling, resulting in lamellipodium-based fast cell spreading. Meanwhile, on surfaces with immobile ligands, αvβ3 and α5β1 integrins synergistically initiate intracellular-force-based canonical mechanotransduction pathways to enhance cell adhesion and osteogenic differentiation of stem cells. These results indicate the presence of heretofore-unrecognized pathways, distinct from canonical actomyosin-driven mechanisms, that are capable of promoting cell adhesion.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Zelluläre Biomechanik > Lehrstuhl Zelluläre Biomechanik - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften |
| Eingestellt am: | 07 Jun 2023 11:32 |
| Letzte Änderung: | 07 Jun 2023 11:32 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/81216 |