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Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue Engineering Application

Title data

Xu, Chengzhang ; Cheong, Jun Young ; Mo, Xiumei ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema ; Gharibi, Reza ; Greiner, Andreas:
Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue Engineering Application.
In: Macromolecular Bioscience. Vol. 23 (2023) Issue 11 . - 2300143.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202300143

Official URL: Volltext

Abstract in another language

Biodegradable electrospun sponges are of interest for various applications including tissue engineering, drug release, dental therapy, plant protection, and plant fertilization. Biodegradable electrospun poly (L-lactide)/poly(ε-caprolactone) (PLLA/PCL) blend fiber-based sponge with hierarchical pore structure is inherently hydrophobic, which is disadvantageous for application in tissue engineering, fertilization, and drug delivery. We report contact angles and model studies for staining with a hydrophilic dye for untreated, plasma-treated, and surfactant treated PLLA/PCL sponges. Thorough hydrophilization of PLLA/PCL sponges was found only with the surfactant treated sponges. The MTT assay on the leachates from the sponges did not indicate any cell incompatibility. Furthermore, the cell proliferation and penetration of the hydrophilized sponges were verified by in vitro cell culture studies using MG63 and human fibroblast cells.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: polylactide; electrospun sponges; hydrophilization; human cell tests
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Research Institutions > Collaborative Research Centers, Research Unit > SFB 1357 - MIKROPLASTIK
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 28 Jun 2023 07:56
Last Modified: 05 Feb 2024 08:16
URI: https://eref.uni-bayreuth.de/id/eprint/84905