Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue Engineering Application

Title data

Xu, Chengzhang ; Cheong, Jun Young ; Mo, Xiumei ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema ; Gharibi, Reza ; Greiner, Andreas:
Thoroughly Hydrophilized Electrospun Poly(L-Lactide)/ Poly(ε-Caprolactone) Sponges for Tissue Engineering Application.
In: Macromolecular Bioscience. (2023) . - 2300143.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202300143

Official URL:

Abstract in another language

Biodegradable electrospun sponges are of interest for various applications including tissue engineering, drug release, dental therapy, plant protection, and plant fertilization. Biodegradable electrospun poly (L-lactide)/poly(ε-caprolactone) (PLLA/PCL) blend fiber-based sponge with hierarchical pore structure is inherently hydrophobic, which is disadvantageous for application in tissue engineering, fertilization, and drug delivery. We report contact angles and model studies for staining with a hydrophilic dye for untreated, plasma-treated, and surfactant treated PLLA/PCL sponges. Thorough hydrophilization of PLLA/PCL sponges was found only with the surfactant treated sponges. The MTT assay on the leachates from the sponges did not indicate any cell incompatibility. Furthermore, the cell proliferation and penetration of the hydrophilized sponges were verified by in vitro cell culture studies using MG63 and human fibroblast cells.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	polylactide; electrospun sponges; hydrophilization; human cell tests
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Result of work at the UBT:	Yes
DDC Subjects:	500 Science > 570 Life sciences, biology 600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 600 Technology 600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited:	28 Jun 2023 07:56
Last Modified:	13 Jul 2023 12:12
URI:	https://eref.uni-bayreuth.de/id/eprint/84905