at Google ScholarTitle data
Bishop, Christopher A. ; Machate, Tina ; Henning, Thorsten ; Henkel, Janin ; Püschel, Gerhard ; Weber, Daniela ; Grune, Tilman ; Klaus, Susanne ; Weitkunat, Karolin:
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.
In: Nutrition & Diabetes.
Vol. 12
(2022)
.
- 20.
ISSN 2044-4052
DOI: https://doi.org/10.1038/s41387-022-00200-8
Abstract in another language
OBJECTIVE: Current data regarding the roles of branched-chain amino acids (BCAA) in metabolic health are rather conflicting, as positive and negative effects have been attributed to their intake.
METHODS: To address this, individual effects of leucine and valine were elucidated in vivo (C57BL/6JRj mice) with a detailed phenotyping of these supplementations in high-fat (HF) diets and further characterization with in vitro approaches (C2C12 myocytes).
RESULTS: Here, we demonstrate that under HF conditions, leucine mediates beneficial effects on adiposity and insulin sensitivity, in part due to increasing energy expenditure—likely contributing partially to the beneficial effects of a higher milk protein intake. On the other hand, valine feeding leads to a worsening of HF-induced health impairments, specifically reducing glucose tolerance/
insulin sensitivity. These negative effects are driven by an accumulation of the valine-derived metabolite 3-hydroxyisobutyrate (3-HIB). Higher plasma 3-HIB levels increase basal skeletal muscle glucose uptake which drives glucotoxicity and impairs myocyte insulin signaling.
CONCLUSION: These data demonstrate the detrimental role of valine in an HF context and elucidate additional targetable
pathways in the etiology of BCAA-induced obesity and insulin resistance.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Life Sciences: Food, Nutrition and Health Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung > Lehrstuhl Biochemie der Ernährung - Univ.-Prof. Dr. Janin Henkel-Oberländer |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science 500 Science > 570 Life sciences, biology 600 Technology, medicine, applied sciences > 610 Medicine and health |
| Date Deposited: | 18 Sep 2023 08:34 |
| Last Modified: | 18 Sep 2023 08:34 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/86873 |