Title data
Püschel, Gerhard Paul ; Klauder, Julia ; Henkel, Janin:
Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia : A Mutual Ambiguous Relationship in the Development of Metabolic Diseases.
In: Journal of Clinical Medicine.
Vol. 11
(2022)
Issue 15
.
- 4358.
ISSN 2077-0383
DOI: https://doi.org/10.3390/jcm11154358
Project information
Project financing: |
Deutsche Forschungsgemeinschaft |
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Abstract in another language
Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which present a very heterogeneous population of cells, play a key role in the maintenance of normal tissue homeostasis, but functional alterations in the resident macrophage pool as well as newly recruited monocyte-derived macrophages are important drivers in the development of low-grade inflammation. While metabolic dysfunction, insulin resistance and tissue damage may trigger or advance pro-inflammatory responses in macrophages, the inflammation itself contributes to the development of insulin resistance and the resulting hyperinsulinemia. Macrophages express insulin receptors whose downstream signaling networks share a number of knots with the signaling pathways of pattern recognition and cytokine receptors, which shape macrophage polarity. The shared knots allow insulin to enhance or attenuate both pro-inflammatory and anti-inflammatory macrophage responses. This supposedly physiological function may be impaired by hyperinsulinemia or insulin resistance in macrophages. This review discusses the mutual ambiguous relationship of low-grade inflammation, insulin resistance, hyperinsulinemia and the insulin-dependent modulation of macrophage activity
with a focus on adipose tissue and liver.
Further data
Item Type: | Article in a journal |
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Refereed: | Yes |
Institutions of the University: | Faculties > Faculty of Life Sciences: Food, Nutrition and Health Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung Faculties > Faculty of Life Sciences: Food, Nutrition and Health > Lehrstuhl Biochemie der Ernährung > Lehrstuhl Biochemie der Ernährung - Univ.-Prof. Dr. Janin Henkel-Oberländer |
Result of work at the UBT: | Yes |
DDC Subjects: | 500 Science 500 Science > 570 Life sciences, biology 600 Technology, medicine, applied sciences > 610 Medicine and health |
Date Deposited: | 18 Sep 2023 08:40 |
Last Modified: | 18 Sep 2023 08:40 |
URI: | https://eref.uni-bayreuth.de/id/eprint/86874 |