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Biofabrication of Composite Bioink-Nanofiber Constructs : Effect of Rheological Properties of Bioinks on 3D (Bio)Printing and Cells Interaction with Aligned Touch Spun Nanofibers

Title data

Kitana, Waseem ; Levario Diaz, Victoria ; Cavalcanti-Adam, Elisabetta Ada ; Ionov, Leonid:
Biofabrication of Composite Bioink-Nanofiber Constructs : Effect of Rheological Properties of Bioinks on 3D (Bio)Printing and Cells Interaction with Aligned Touch Spun Nanofibers.
In: Advanced Healthcare Materials. Vol. 13 (2024) Issue 6 . - 2303343.
ISSN 2192-2659
DOI: https://doi.org/10.1002/adhm.202303343

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft
IO 68/14-1 326998133 - TRR 225 subproject A08

Abstract in another language

This paper reports on a novel approach for the fabrication of composite multilayered bioink-nanofibers construct. This work achieves this by using a hands-free 3D (bio)printing integrated touch-spinning approach. Additionally, this work investigates the interaction of fibroblasts in different bioinks with the highly aligned touch-spun nanofibers. This work conducts a comprehensive characterization of the rheological properties of the inks, starting with low-strain oscillatory rheology to analyze the viscoelastic behavior, when the material structure remains intact. Moreover, this work performs amplitude sweeps to investigate the stability of the inks under large deformations, rotational rheology to examine the shear thinning profile, and a three-step creep experiment to study time-dependent rheological behavior. The obtained rheological results are correlated to visual observation of the flow behavior of inks. These behaviors span from an ink with zero-shear viscosity, very weak shear thinning, and no thixotropic behavior to inks exhibiting flow stress, pronounced shear thinning, and thixotropy. It is demonstrated that inks have an essential effect on cell behavior. While all bioinks allow a preferred directionality of the fibroblasts along the fiber direction, cells tend to form aggregates in bioinks with higher viscosity, and a considerable number of agglomerates are observed in the presence of laponite-RD.

Further data

Item Type: Article in a journal
Refereed: No
Keywords: 3D biofabrication; bioink; cell motility; cell orientation; extrusion 3D
(bio)printing; rheology; touch-spinning
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics > Chair Cellular Biomechanics - Univ.-Prof. Dr. Dr. Elisabetta Ada Cavalcanti-Adam
Faculties > Faculty of Engineering Science > Professor Biofabrication > Professor Biofabrication - Univ.-Prof. Dr. Leonid Ionov
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Cellular Biomechanics
Faculties > Faculty of Engineering Science > Professor Biofabrication
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 600 Technology
Date Deposited: 29 Nov 2023 07:46
Last Modified: 11 Mar 2024 08:52
URI: https://eref.uni-bayreuth.de/id/eprint/87900