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Influence of the polymer type of a microplastic challenge on the reaction of murine cells

Title data

Jasinski, Julia ; Völkl, Matthias ; Wilde, Magdalena V. ; Jérôme, Valérie ; Fröhlich, Thomas ; Freitag, Ruth ; Scheibel, Thomas:
Influence of the polymer type of a microplastic challenge on the reaction of murine cells.
In: Journal of Hazardous Materials. Vol. 465 (2024) . - 133280.
ISSN 0304-3894

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Due to global pollution derived from plastic waste, the research on microplastics is of increasing public interest. Until now, most studies addressing the effect of microplastic particles on vertebrate cells have primarily utilized polystyrene particles (PS). Other studies on polymer microparticles made, e.g., of polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), or poly (ethylene terephthalate) (PET), cannot easily be directly compared to these PS studies, since the used microparticles differ widely in size and surface features. Here, effects caused by pristine microparticles of a narrow size range between 1 - 4µm from selected conventional polymers including PS, PE, and PVC, were compared to those of particles made of polymers derived from biological sources like polylactic acid (PLA), and cellulose acetate (CA). The microparticles were used to investigate cellular uptake and assess cytotoxic effects on murine macrophages and epithelial cells. Despite differences in the particles' properties (e.g. ζ-potential and surface morphology), macrophages were able to ingest all tested particles, whereas epithelial cells ingested only the PS-based particles, which had a strong negative ζ-potential. Most importantly, none of the used model polymer particles exhibited significant short-time cytotoxicity, although the general effect of environmentally relevant microplastic particles on organisms requires further investigation. Environmental Implication Our study contributes to a better understanding of microplastics toxicology, which appears to be dependent on cell type and also on the polarization state of such cells. This information is essential, as sound knowledge on the characteristics driving microplastic toxicity on organisms may explain the often contradictory results observed in effect studies on microplastics and will help to advance risk assessment for microplastic particles.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: polymer particles; cellulose acetate microparticles; particle-cell interaction; protein corona; reactive oxygen species
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Research Institutions > Collaborative Research Centers, Research Unit > SFB 1357 - MIKROPLASTIK
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 600 Technology
600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 10 Jan 2024 06:44
Last Modified: 10 Jan 2024 06:44