A Fast Degrading Odd–Odd Aliphatic Polyester-5,7 Made by Condensation Polymerization for Biomedical Applications

Titelangaben

Chen, Fei ; Nölle, Jan Martin ; Wietzke, Steffen ; Reuter, Marco ; Chatterjee, Sangam ; Koch, Martin ; Agarwal, Seema:
A Fast Degrading Odd–Odd Aliphatic Polyester-5,7 Made by Condensation Polymerization for Biomedical Applications.
In: Journal of Biomaterials Science, Polymer Edition. Bd. 23 (2012) Heft 12 . - S. 1539-1551.
ISSN 0920-5063
DOI: https://doi.org/10.1163/092050611X585837

Volltext

Link zum Volltext (externe URL):

Abstract

Abstract A fast enzymatic degradable aliphatic all-odd-polyester-5,7, based on 1,7-heptanedioic acid (pimelic acid) and 1,5-pentanediol, was synthesized by polycondensation. The structural characterization of the polyester was done using 1D- and 2D-NMR spectroscopic techniques. The properties of the resulting polyester-like crystallization behavior, enzymatic degradation, thermal stability, etc., were investigated using differential scanning calorimetry, wide-angle X-ray diffraction, scanning electron microscopy and gel-permeation chromatography. Terahertz time-domain spectroscopy was employed to determine the glass transition temperature, which could not be revealed reliably by conventional thermal analysis. The properties of all-odd-polyester-5,7 were compared with a well-known enzymatic degradable polyester (polycaprolactone). The results indicated that polyester-5,7 has a crystal structure similar to PCL, but a much faster degradation rate. The morphology of polyester-5,7 film during enzymatic degradation showed a fibrillar structure and degradation began by surface erosion.