Functional Degradable Polymers via Radical Ring-Opening Polymerization and Click Chemistry

Titelangaben

Maji, Samarendra ; Zheng, Mengyao ; Agarwal, Seema:
Functional Degradable Polymers via Radical Ring-Opening Polymerization and Click Chemistry.
In: Macromolecular Chemistry and Physics. Bd. 212 (2011) Heft 23 . - S. 2573-2582.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201100375

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Abstract

The use of free-radical polymerization for the formation of an alkyne-functionalized polymer with ester units of polycaprolactone type in the backbone is shown. This is done by the copolymerization of a cyclic ketene acetal 2-methylene-1,3-dioxepane (MDO) with propargyl acrylate using a free radical initiator, azobis(isobutyronitrile). Structural characterization of the copolymers using 1D and 2D NMR techniques shows the random distribution and very high percentage of inclusion of alkyne groups onto the polymer backbone. The exemplary grafting of a biocompatible polymer poly(ethylene glycol) via azide-alkyne “click” chemistry is also shown. Hydrolytic degradation behavior and biocompatibility of the polymers (cytotoxicity) studies are also reported.