Institutions of the University of Bayreuth
Professor Organische Chemie IV - Biotechnologie und Chemie der Lebensmittel und Wirkstoffe - Univ.-Prof. Dr. Frank Hahn

Nguyen, Lisa ; Derra, Sebastian ; Hahn, Frank:
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases : A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precursor Analogues.
In: ACS Chemical Biology. Vol. 20 (2025) . - pp. 186-196.
DOI: https://doi.org/10.1021/acschembio.4c00669

Rydzek, Simon ; Guth, Florian ; Friedrich, Steffen ; Noske, Jakob ; Höcker, Birte ; Hahn, Frank:
Chemoenzymatic Synthesis of Plant‐Derived Kavalactone Natural Products by Dynamic Resolution Using a Biosynthetic O‐Methyltransferase Tailoring Enzyme.
In: ChemCatChem. Vol. 16 (2024) Issue 23 . - e202400883.
DOI: https://doi.org/10.1002/cctc.202400883

Roß-Taschner, Theresa ; Derra, Sebastian ; Stang, Jörg ; Schlotte, Luca ; Putratama, Anthony ; Hahn, Frank:
Highly Stereoselective Biocatalytic One-Pot Synthesis of Chiral Saturated Oxygen Heterocycles by Integration of a Biosynthetic Heterocyclase into Multiple-Enzyme Cascades.
In: ACS Catalysis. Vol. 14 (2024) . - pp. 13420-13428.
DOI: https://doi.org/10.1021/acscatal.4c03692

Derra, Sebastian ; Hoffmann, Julia ; Hahn, Frank:
Synthesis of Biomimetic Thioesters for Studies of Ketoreductase Domains from the Biosynthesis of Cytotoxic Polyketides.
In: Synlett. Vol. 35 (2024) Issue 14 . - pp. 1707-1712.
DOI: https://doi.org/10.1055/a-2216-4521

Guth, Florian ; Lindner, Frederick ; Rydzek, Simon ; Peil, Andreas ; Friedrich, Steffen ; Hauer, Bernhard ; Hahn, Frank:
Rieske Oxygenase-Catalyzed Oxidative Late-Stage Functionalization during Complex Antifungal Polyketide Biosynthesis.
In: ACS Chemical Biology. Vol. 18 (2023) Issue 12 . - pp. 2450-2456.
DOI: https://doi.org/10.1021/acschembio.3c00498

Derra, Sebastian ; Schlotte, Luca ; Hahn, Frank:
Suzuki–Miyaura Reaction in the Presence of N-Acetylcysteamine Thioesters Enables Rapid Synthesis of Biomimetic Polyketide Thioester Surrogates for Biosynthetic Studies.
In: Chemistry. Vol. 5 (2023) Issue 2 . - pp. 1407-1418.
DOI: https://doi.org/10.3390/chemistry5020096

Schröder, Marius ; Roß, Theresa ; Hemmerling, Franziska ; Hahn, Frank:
Studying a bottleneck of multimodular polyketide synthase processing : the polyketide structure-dependent performance of ketoreductase domains.
In: ACS Chemical Biology. Vol. 17 (2022) Issue 5 . - pp. 1030-1037.
DOI: https://doi.org/10.1021/acschembio.2c00047

Wagner, Lisa Maria Carolin ; Stang, Jörg ; Derra, Sebastian ; Hollmann, Tim ; Hahn, Frank:
Towards understanding oxygen heterocycle-forming biocatalysts : a selectivity study of the pyran synthase PedPS7.
In: Organic & Biomolecular Chemistry. Vol. 20 (2022) Issue 48 . - pp. 9645-9649.
DOI: https://doi.org/10.1039/D2OB02064E

Wagner, Lisa Maria Carolin ; Roß, Theresa ; Hollmann, Tim ; Hahn, Frank:
Cross-linking of a polyketide synthase domain leads to a recyclable biocatalyst for chiral oxygen heterocycle synthesis.
In: RSC Advances. Vol. 11 (2021) Issue 33 . - pp. 20248-20251.
DOI: https://doi.org/10.1039/D1RA03692K

Hahn, Frank ; Guth, Florian:
The ambruticins and jerangolids : chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates.
In: Natural Product Reports. Vol. 37 (2020) Issue 10 . - pp. 1300-1315.
DOI: https://doi.org/10.1039/D0NP00012D

Hollmann, Tim ; Berkhan, Gesche ; Wagner, Lisa Maria Carolin ; Sung, Kwang Hoon ; Kolb, Simon ; Geise, Hendrik ; Hahn, Frank:
Biocatalysts from Biosynthetic Pathways : Enabling Stereoselective, Enzymatic Cycloether Formation on A Gram Scale.
In: ACS Catalysis. Vol. 10 (2020) . - pp. 4973-4982.
DOI: https://doi.org/10.1021/acscatal.9b05071

Wunderlich, Johannes ; Roß, Theresa ; Schröder, Marius ; Hahn, Frank:
Step-Economic Synthesis of Biomimetic β-Ketopolyene Thioesters and Demonstration of Their Usefulness in Enzymatic Biosynthesis Studies.
In: Organic Letters. Vol. 22 (2020) Issue 13 . - pp. 4955-4959.
DOI: https://doi.org/10.1021/acs.orglett.0c01348

Hahn, Frank:
Heterocycle biosynthesis via C-H functionalization.
In: Nature Catalysis. Vol. 1 (2018) . - pp. 905-906.
DOI: https://doi.org/10.1038/s41929-018-0194-2

Sung, Kwang Hoon ; Berkhan, Gesche ; Hollmann, Tim ; Wagner, Lisa Maria Carolin ; Blankenfeldt, Wulf ; Hahn, Frank:
Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain.
In: Angewandte Chemie International Edition. Vol. 57 (2018) Issue 1 . - pp. 343-347.
DOI: https://doi.org/10.1002/anie.201707774

Lindner, Frederick ; Friedrich, Steffen ; Hahn, Frank:
Total Synthesis of Complex Biosynthetic Late-Stage Intermediates and Bioconversion by a Tailoring Enzyme from Jerangolid Biosynthesis.
In: The Journal of Organic Chemistry. Vol. 83 (2018) Issue 22 . - pp. 14091-14101.
DOI: https://doi.org/10.1021/acs.joc.8b02047

Hemmerling, Franziska ; Lebe, Karen E. ; Wunderlich, Johannes ; Hahn, Frank:
An Unusual Fatty Acyl:Adenylate Ligase (FAAL)–Acyl Carrier Protein (ACP) Didomain in Ambruticin Biosynthesis.
In: ChemBioChem. Vol. 19 (2018) Issue 10 . - pp. 1006-1011.
DOI: https://doi.org/10.1002/cbic.201800084

Hemmerling, Franziska ; Hahn, Frank:
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.
In: Beilstein Journal of Organic Chemistry. Vol. 12 (2016) . - pp. 1512-1550.
DOI: https://doi.org/10.3762/bjoc.12.148

Friedrich, Steffen ; Hemmerling, Franziska ; Lindner, Frederick ; Warnke, Anna ; Wunderlich, Johannes ; Berkhan, Gesche ; Hahn, Frank:
Characterisation of the Broadly-Specific O-Methyl-transferase JerF from the Late Stages of Jerangolid Biosynthesis.
In: Molecules. Vol. 21 (2016) Issue 11 . - 1443.
DOI: https://doi.org/10.3390/molecules21111443

Berkhan, Gesche ; Merten, Christian ; Holec, Claudia ; Hahn, Frank:
The Interplay between a Multifunctional Dehydratase Domain and a C-Methyltransferase Effects Olefin Shift in Ambruticin Biosynthesis.
In: Angewandte Chemie International Edition. Vol. 55 (2016) Issue 43 . - pp. 13589-13592.
DOI: https://doi.org/10.1002/anie.201607827

Friedrich, Steffen ; Hahn, Frank:
Opportunities for enzyme catalysis in natural product chemistry.
In: Tetrahedron. Vol. 71 (2015) Issue 10 . - pp. 1473-1508.
DOI: https://doi.org/10.1016/j.tet.2014.12.026

Berkhan, Gesche ; Hahn, Frank:
A Dehydratase Domain in Ambruticin Biosynthesis Displays Additional Activity as a Pyran-Forming Cyclase.
In: Angewandte Chemie International Edition. Vol. 53 (2014) Issue 15 . - pp. 14240-14244.
DOI: https://doi.org/10.1002/anie.201407979

Hemmerling, Franziska ; Hahn, Frank:
Neue Wege in der Naturstoffforschung : Die erfolgreiche Verbindung von Synthesechemie und Biotechnologie.
In: GIT : Labor-Fachzeitschrift. Vol. 58 (2014) Issue 5 . - p. 48.

Hahn, Frank ; Kandziora, Nadine ; Friedrich, Steffen ; Leadlay, Peter F.:
Synthesis of complex intermediates for the study of a dehydratase from borrelidin biosynthesis.
In: Beilstein Journal of Organic Chemistry. Vol. 10 (2014) . - pp. 634-640.
DOI: https://doi.org/10.3762/bjoc.10.55

Kandziora, Nadine ; Andexer, Jennifer N. ; Moss, Steven J. ; Wilkinson, Barrie ; Leadlay, Peter F. ; Hahn, Frank:
Uncovering the origin of Z-configured double bonds in polyketides : intermediate E-double bond formation during borrelidin biosynthesis.
In: Chemical Science. Vol. 5 (2014) Issue 9 . - pp. 3563-3567.
DOI: https://doi.org/10.1039/C4SC00883A

Fürniss, Daniel ; Mack, Timo ; Hahn, Frank ; Vollrath, Sidonie B. L. ; Koroniak, Katarzyna ; Schepers, Ute ; Bräse, Stefan:
Peptoids and polyamines going sweet : Modular synthesis of glycosylated peptoids and polyamines using click chemistry.
In: Beilstein Journal of Organic Chemistry. Vol. 9 (2013) . - pp. 56-63.
DOI: https://doi.org/10.3762/bjoc.9.7

Kanchanabanca, Chompoonik ; Tao, Weixin ; Hong, Hui ; Liu, Yajing ; Hahn, Frank ; Samborskyy, Markiyan ; Deng, Zixin ; Sun, Yuhui ; Leadlay, Peter F.:
Unusual Acetylation–Elimination in the Formation of Tetronate Antibiotics.
In: Angewandte Chemie International Edition. Vol. 52 (2013) Issue 22 . - pp. 5785-5788.
DOI: https://doi.org/10.1002/anie.201301680

Kirschning, Andreas ; Hahn, Frank:
Merging Chemical Synthesis and Biosynthesis : A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries.
In: Angewandte Chemie International Edition. Vol. 51 (2012) Issue 17 . - pp. 4012-4022.
DOI: https://doi.org/10.1002/anie.201107386

Vergnolle, Olivia ; Hahn, Frank ; Baerga-Ortiz, Abel ; Leadlay, Peter F. ; Andexer, Jennifer N.:
Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase : Implications for cis Double Bond Formation.
In: ChemBioChem. Vol. 12 (2011) Issue 7 . - pp. 1011-1014.
DOI: https://doi.org/10.1002/cbic.201100011

Sun, Yuhui ; Hahn, Frank ; Demydchuk, Yuliya ; Chettle, James ; Tosin, Manuela ; Osada, Hiroyuki ; Leadlay, Peter F.:
In vitro reconstruction of tetronate RK-682 biosynthesis.
In: Nature Chemical Biology. Vol. 6 (2010) . - pp. 99-101.
DOI: https://doi.org/10.1038/nchembio.285

Schmitz, Katja ; Hahn, Frank ; Schepers, Ute:
Modified GSMP Synthesis Greatly Improves the Disulfide Crosslink of T7 Run-Off siRNAs with Cell Penetrating Peptides.
In: Synlett. (2010) Issue 19 . - pp. 2959-2963.
DOI: https://doi.org/10.1055/s-0030-1259022

Chavarot-Kerlidou, Murielle ; Rivard, Michaël ; Chamiot, Bénédicte ; Hahn, Frank ; Rose-Munch, Françoise ; Rose, Eric ; Py, Sandrine ; Herson, Patrick:
Synthesis and Structural Characterization of Planar Chiral Cr(CO)3-Complexed Aromatic Nitrones : Valuable Substrates for Asymmetric SmI2-Induced Coupling Reactions.
In: European Journal of Organic Chemistry. (2010) Issue 5 . - pp. 944-958.
DOI: https://doi.org/10.1002/ejoc.200900836

Hahn, Frank ; Schepers, Ute:
Thieme Chemistry Journal Awardees - Where are They Now? : A Convenient Route for Introduction of Lipophilic Side Chains in Polyamine Backbones by Solid-Phase Synthesis.
In: Synlett. (2009) Issue 17 . - pp. 2755-2760.
DOI: https://doi.org/10.1055/s-0029-1217987

Hahn, Frank ; Müllen, Klaus ; Schepers, Ute:
2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis.
In: Synlett. (2008) Issue 18 . - pp. 2785-2790.
DOI: https://doi.org/10.1055/s-0028-1083566

Hahn, Frank ; Schmitz, Katja ; Balaban, Theodor S. ; Bräse, Stefan:
Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins.
In: ChemMedChem. Vol. 3 (2008) Issue 8 . - pp. 1185-1188.
DOI: https://doi.org/10.1002/cmdc.200800013

Hahn, Frank ; Schepers, Ute:
Versatile Procedure for Asymmetric and Orthogonal Protection of Symmetric Polyamines and Its Advantages for Solid Phase Synthesis.
In: Journal of Combinatorial Chemistry. Vol. 10 (2008) Issue 2 . - pp. 267-272.
DOI: https://doi.org/10.1021/cc700119g

Hahn, Frank ; Schepers, Ute:
Solid Phase Chemistry for the Directed Synthesis of Biologically Active Polyamine Analogs, Derivatives, and Conjugates.
In: Bräse, Stefan (ed.): Combinatorial chemistry on solid supports. - Berlin : Springer, 2007 . - pp. 135-208 . - (Topics in Current Chemistry ; 278 )

Guth, Florian:
Studien zu den RIESKE-Oxygenasen JerP und JerL der Jerangolid Biosynthese.
Bayreuth , 2025 . - VII, 286 p.
( Doctoral thesis, 2025 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00008387

Wunderlich, Johannes:
Studien zur Biosynthese des Ambruticin-Mittelfragments.
Bayreuth , 2023 . - 287 p.
( Doctoral thesis, 2023 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006999

Wagner, Lisa Maria Carolin:
Enzymatische Synthese von chiralen, mehrfach substituierten Heterozyklen durch Verwendung einer neuartigen Gruppe von Zyklasen.
Bayreuth , 2022 . - XIII, 366 p.
( Doctoral thesis, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006593

Hollmann, Tim:
Untersuchung von Zyklasen als neuartige Biokatalysatoren für die Heterozyklensynthese.
Bayreuth , 2022 . - VI, 298 p.
( Doctoral thesis, 2021 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005978

Schröder, Marius:
In vitro-Studien isolierter Ketoreduktase-Domänen der Polyketidbiosynthese.
Bayreuth , 2021 . - XIII, 344 p.
( Doctoral thesis, 2020 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005784

Lindner, Frederick:
Etablierung chemoenzymatischer Totalsynthesen der Jerangolide.
Bayreuth , 2019 . - VI, 279 p.
( Doctoral thesis, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004527