Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging

Titelangaben

Pfaff, André ; Schallon, Anja ; Ruhland, Thomas M. ; Majewski, Alexander P. ; Schmalz, Holger ; Freitag, Ruth ; Müller, Axel H. E.:
Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging.
In: Biomacromolecules. Bd. 12 (2011) Heft 10 . - S. 3805-3811.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm201051p

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Abstract

The synthesis of galactose-displaying core-shell exhibiting and magnetic properties by grafting a glycocopolymer consisting of 6-O-methacryloylgalactopyranose (MAGal) and 4-(pyrenyl)butynl methacrylate (PyMA) onto magnetic silica particles via thiol-ene chemistry is reported Magnetization measurements indicated that neither the encapsulation of the iron oxide particles into silica nor the grafting of the glycocopolymer chains had a significant influence on the superparamagnetic properties. This not only simplifies the purification of the particles but may facilitate the use of the particles in applications such as hyperthermia or magnetic resonance imaging (MRI). Furthermore, the hydrophilic glycopolymer shell provided solubility of the particles in aqueous medium and enabled the uptake of the particles into the cytoplasm and nucleus of lung cancer cells via carbohydrate-lectin recognition effects.