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pH-Dependent Dimerization and Salt-Dependent Stabilization of the N-terminal Domain of Spider Dragline Silk—Implications for Fiber Formation

Title data

Hagn, Franz ; Thamm, Christopher ; Scheibel, Thomas ; Kessler, Horst:
pH-Dependent Dimerization and Salt-Dependent Stabilization of the N-terminal Domain of Spider Dragline Silk—Implications for Fiber Formation.
In: Angewandte Chemie International Edition. Vol. 50 (3 January 2011) Issue 1 . - pp. 310-313.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201003795

Official URL: Volltext

Abstract in another language

One of the toughest protein fibers: The N-terminal domain (NTD) of spider dragline silk shows a pH-dependent monomer–dimer equilibrium: The N-terminal domain silk protein is stored as a stabilized monomer at neutral pH and high salt concentration, whereas during fiber assembly at a lower pH value this domain is able to form antiparallel dimers. Multivalent linking results in endless and highly stable fibers (see picture).

Abstract in another language

Eine der festesten bekannten Proteinfasern: Die N-terminale Domäne (NTD) von Abseilfaden-Spinnenseide zeigt ein pH-abhängiges Monomer-Dimer-Gleichgewicht: Die N-terminalen Domänen der Seidenproteine werden im neutralen pH-Bereich und bei hohen Salzkonzentrationen als stabilisierte Monomere gespeichert, bei der Faserbildung bei niedrigem pH-Wert können sich diese Domänen jedoch zu antiparallelen Dimeren zusammenlagern. Durch multivalente Verknüpfung entstehen sehr stabile endlose Fasern.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biopolymers; circular dichroism; NMR spectroscopy; protein folding; protein structure
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 07 Jul 2015 07:25
Last Modified: 26 Nov 2015 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/15789