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Hardy, John G. ; Torres-Rendon, Jose Guillermo ; Leal-Egaña, Aldo ; Walther, Andreas ; Schlaad, Helmut ; Cölfen, Helmut ; Scheibel, Thomas:
Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering.
In: Materials.
Bd. 9
(2016)
Heft 7
.
- 560.
ISSN 1996-1944
DOI: https://doi.org/10.3390/ma9070560
Abstract
Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT)or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)),that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering