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Microfluidics-Produced Collagen Fibers Show Extraordinary Mechanical Properties

Title data

Haynl, Christian ; Hofmann, Eddie ; Pawar, Kiran ; Förster, Stephan ; Scheibel, Thomas:
Microfluidics-Produced Collagen Fibers Show Extraordinary Mechanical Properties.
In: Nano Letters. (11 August 2016) .
ISSN 1530-6992
DOI: https://doi.org/10.1021/acs.nanolett.6b02828

Abstract in another language

Collagens are widely used as biomaterials in drug-delivery and tissue engineering applications due to their biodegradability, biocompatibility and hypoallergenicity. Besides gelatin-based materials, collagen microfibers are in the focus of biomedical research. Commonly, man-made fibers are produced by wet-spinning yielding fiber diameters higher than 8 μm. Here, assembly and continuous production of single collagen type I microfibers were established using a microfluidic chip. Microfluidics-produced microfibers exhibited tensile strength and Young’s modulus exceeding that of fibers produced in classical wet-spinning devices and even that of natural tendon and they showed lower diameters. Their structural orientation was examined by polarized Fourier transform infrared spectroscopy (FTIR) showing fibril alignment within the microfiber. Cell culture tests using the neuronal cell line NG108-15 showed cell alignment and axon growth along the microfiber axes inaugurating potential applications in, for example, peripheral nerve repair.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: axon growth; biomaterial; Collagen; mechanical properties; microfiber; microfluidics
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 18 Aug 2016 09:41
Last Modified: 18 Aug 2016 09:41
URI: https://eref.uni-bayreuth.de/id/eprint/34168