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Surface Modification of Polymeric Biomaterials Using Recombinant Spider Silk Proteins

Title data

Borkner, Christian B. ; Wohlrab, Stefanie ; Möller, Eva ; Lang, Gregor ; Scheibel, Thomas:
Surface Modification of Polymeric Biomaterials Using Recombinant Spider Silk Proteins.
In: ACS Biomaterials Science & Engineering. (August 2016) .
ISSN 2373-9878
DOI: https://doi.org/10.1021/acsbiomaterials.6b00306

Abstract in another language

The performance of biomaterials largely depends on the materials biocompatibility, which is directly related to unwanted side effects like foreign body responses and inflammation, and the potential of interaction of cells with its surface, for example, cell adhesion. In the distinct application of catheters, low or even no cell adhesion is eligible. To influence the properties of existing and commonly used biomaterials and to further increase their biocompatibility, a coating with a recombinantly produced spider silk protein as outer layer was applied on three selected catheter polymers (polyurethane, polytetrafluoroethylene, silicone) and evaluated based on cell adhesion. The tested cell types, HaCaT keratinocytes (epidermal cells), B50 neuronal cells, C2C12 myoblasts (muscle cells) and BALB/3T3 fibroblasts (connective tissue), exhibited low or no adhesion on the silk-coated materials. In combination with the lack of toxicity, the good biocompatibility, and the low body response, it could be shown that silk coatings have a high potential as a biomedical coating material, e.g., for catheters.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biodegradation; biomaterial coating; catheter; cell adhesion; recombinant spider silk proteins
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 14 Sep 2016 07:00
Last Modified: 14 Sep 2016 07:00
URI: https://eref.uni-bayreuth.de/id/eprint/34702