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Probing the adhesion properties of alginate hydrogels : a new approach towards the preparation of soft colloidal probes for direct force measurements

Titelangaben

Helfricht, Nicolas ; Doblhofer, Elena ; Bieber, Vera ; Lommes, Petra ; Sieber, Volker ; Scheibel, Thomas ; Papastavrou, Georg:
Probing the adhesion properties of alginate hydrogels : a new approach towards the preparation of soft colloidal probes for direct force measurements.
In: Soft Matter. (15 Dezember 2016) .
ISSN 1744-6848
DOI: https://doi.org/10.1039/C6SM02326F

Abstract

The adhesion of alginate hydrogels to solid surfaces was probed by atomic force microscopy (AFM) in the
sphere/plane geometry. For this purpose a novel approach has been developed for the immobilization of
soft colloidal probes onto AFM-cantilevers, which is inspired by techniques originating from cell biology.
The aspiration and consecutive manipulation of hydrogel beads by micropipettes allows the entire
manipulation sequence to be carried-out in situ. Hence, any alteration of the hydrogel beads upon drying
can be excluded. The adhesive behaviour of alginate hydrogels was first evaluated by determining the
distribution of pull-off forces on self-assembled monolayers (SAMs) terminating in different functional
groups (–CH3, –OH, –NH2, –COOH). It was demonstrated that solvent exclusion plays practically no
role in the adhesion process, in clear difference to solid colloidal probes. The adhesion of alginate beads is
dominated by chemical interactions rather than solvent exclusion, in particular in the case of aminoterminated
SAMs. The data set acquired on the SAMs provided the framework to relate the adhesion of
alginate beads on recombinant spider silk protein films to specific functional groups. The preparation
of soft colloidal probes and the presented approach in analysing the adhesive behaviour is not limited
to alginate hydrogel beads but can be generally applied for probing and understanding the adhesion behaviour
of hydrogels on a wide range of substrates, which would be relevant for various applications such as
biomedical surface modification or tissue engineering.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien > Lehrstuhl Biomaterialien - Univ.-Prof. Dr. Thomas Scheibel
Profilfelder
Profilfelder > Advanced Fields
Profilfelder > Advanced Fields > Polymer- und Kolloidforschung
Profilfelder > Advanced Fields > Neue Materialien
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Profilfelder > Emerging Fields
Profilfelder > Emerging Fields > Lebensmittel- und Gesundheitswissenschaften
Forschungseinrichtungen
Forschungseinrichtungen > Forschungszentren
Forschungseinrichtungen > Forschungszentren > Bayreuther Materialzentrum - BayMAT
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Eingestellt am: 13 Jan 2017 10:39
Letzte Änderung: 13 Jan 2017 10:39
URI: https://eref.uni-bayreuth.de/id/eprint/35671