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Probing the adhesion properties of alginate hydrogels : a new approach towards the preparation of soft colloidal probes for direct force measurements

Title data

Helfricht, Nicolas ; Doblhofer, Elena ; Bieber, Vera ; Lommes, Petra ; Sieber, Volker ; Scheibel, Thomas ; Papastavrou, Georg:
Probing the adhesion properties of alginate hydrogels : a new approach towards the preparation of soft colloidal probes for direct force measurements.
In: Soft Matter. (15 December 2016) .
ISSN 1744-6848
DOI: https://doi.org/10.1039/C6SM02326F

Abstract in another language

The adhesion of alginate hydrogels to solid surfaces was probed by atomic force microscopy (AFM) in the
sphere/plane geometry. For this purpose a novel approach has been developed for the immobilization of
soft colloidal probes onto AFM-cantilevers, which is inspired by techniques originating from cell biology.
The aspiration and consecutive manipulation of hydrogel beads by micropipettes allows the entire
manipulation sequence to be carried-out in situ. Hence, any alteration of the hydrogel beads upon drying
can be excluded. The adhesive behaviour of alginate hydrogels was first evaluated by determining the
distribution of pull-off forces on self-assembled monolayers (SAMs) terminating in different functional
groups (–CH3, –OH, –NH2, –COOH). It was demonstrated that solvent exclusion plays practically no
role in the adhesion process, in clear difference to solid colloidal probes. The adhesion of alginate beads is
dominated by chemical interactions rather than solvent exclusion, in particular in the case of aminoterminated
SAMs. The data set acquired on the SAMs provided the framework to relate the adhesion of
alginate beads on recombinant spider silk protein films to specific functional groups. The preparation
of soft colloidal probes and the presented approach in analysing the adhesive behaviour is not limited
to alginate hydrogel beads but can be generally applied for probing and understanding the adhesion behaviour
of hydrogels on a wide range of substrates, which would be relevant for various applications such as
biomedical surface modification or tissue engineering.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 13 Jan 2017 10:39
Last Modified: 13 Jan 2017 10:39
URI: https://eref.uni-bayreuth.de/id/eprint/35671