Titlebar

Export bibliographic data
Literature by the same author
plus on the publication server
plus at Google Scholar

 

Surface Features of Recombinant Spider Silk Protein eADF4(κ16)-Made Materials are Well-Suited for Cardiac Tissue Engineering

Title data

Petzold, Jana ; Aigner, Tamara ; Touska, Filip ; Zimmermann, Katharina ; Engel, Felix B. ; Scheibel, Thomas:
Surface Features of Recombinant Spider Silk Protein eADF4(κ16)-Made Materials are Well-Suited for Cardiac Tissue Engineering.
In: Advanced Functional Materials. (11 August 2017) . - 11 S..
ISSN 1616-301X
DOI: https://doi.org/10.1002/adfm.201701427

Official URL: Volltext

Abstract in another language

Cardiovascular diseases causing high morbidity and mortality represent a major socioeconomic burden. The primary cause of impaired heart function is often the loss of cardiomyocytes. Thus, novel therapies aim at restoring the lost myocardial tissue. One promising approach is cardiac tissue engineering. Previously, it is shown that Antheraea mylitta silk protein fibroin is a suitable material for cardiac tissue engineering, however, its quality is difficult to control. To overcome this limitation, the interaction of primary rat heart cells with engineered Araneus diadematus fibroin 4 (κ16) (eADF4(κ16)) is investigated here, which is engineered based on the sequence of ADF4 by replacing the glutamic acid residue in the repetitive unit of its core domain with lysine. The data demonstrate that cardiomyocytes, fibroblasts, endothelial cells, and smooth muscle cells attach well to eADF4(κ16) films on glass coverslips which provide an engineered surface with a polycationic character. Moreover, eADF4(κ16) films have, in contrast to fibronectin films, no hypertrophic effect but allow the induction of cardiomyocyte hypertrophy. Finally, cardiomyocytes grown on eADF4(κ16) films respond to pro-proliferative factors and exhibit proper cell-to-cell communication and electric coupling. Collectively, these data demonstrate that designed recombinant eADF4(κ16)-based materials are promising materials for cardiac tissue engineering.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: Preprint
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 25 Aug 2017 06:43
Last Modified: 25 Aug 2017 06:43
URI: https://eref.uni-bayreuth.de/id/eprint/39157