bei Google ScholarTitelangaben
Hardy, John G. ; Bertin, Annabelle ; Torres-Rendon, Jose Guillermo ; Leal-Egaña, Aldo ; Humenik, Martin ; Bauer, Felix ; Walther, Andreas ; Cölfen, Helmut ; Schlaad, Helmut ; Scheibel, Thomas:
Facile Photochemical Modification of Silk Protein–Based Biomaterials.
In: Macromolecular Bioscience.
Bd. 18
(2018)
Heft 11
.
- 1800216.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.201800216
Abstract
Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and
rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk
or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk-based materials initiate the
polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk
materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate
potential applications of this type of modification, the polymer-modified silks are mineralized. The PAA- and PMAAfunctionalized
silks are mineralized with calcium carbonate, whereas the PAAm-functionalized silks are mineralized with
silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the
subject of future investigations.