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Facile Photochemical Modification of Silk Protein–Based Biomaterials

Title data

Hardy, John G. ; Bertin, Annabelle ; Torres-Rendon, Jose Guillermo ; Leal-Egaña, Aldo ; Humenik, Martin ; Bauer, Felix ; Walther, Andreas ; Cölfen, Helmut ; Schlaad, Helmut ; Scheibel, Thomas:
Facile Photochemical Modification of Silk Protein–Based Biomaterials.
In: Macromolecular Bioscience. (2018) . - pp. 1-6. - No. 1800216.
ISSN 1616-5187
DOI: https://doi.org/10.1002/mabi.201800216

Abstract in another language

Silk protein–based materials show promise for application as biomaterials for tissue engineering. The simple and
rapid photochemical modification of silk protein–based materials composed of either Bombyx mori silkworm silk
or engineered spider silk proteins (eADF4(C16)) is reported. Radicals formed on the silk-based materials initiate the
polymerization of monomers (acrylic acid, methacrylic acid, or allylamine) which functionalize the surface of the silk
materials with poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), or poly(allylamine) (PAAm). To demonstrate
potential applications of this type of modification, the polymer-modified silks are mineralized. The PAA- and PMAAfunctionalized
silks are mineralized with calcium carbonate, whereas the PAAm-functionalized silks are mineralized with
silica, both of which provide a coating on the materials that may be useful for bone tissue engineering, which will be the
subject of future investigations.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: biomaterials; chemical modification; photochemistry; silkworm silk; spider silk
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 25 Sep 2018 06:07
Last Modified: 25 Sep 2018 06:07
URI: https://eref.uni-bayreuth.de/id/eprint/45877