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Nanoengineered Biomaterials for corneal regeneration

Title data

Wicklein, Vanessa J. ; Singer, Bernhard B. ; Scheibel, Thomas ; Salehi, Sahar:
Nanoengineered Biomaterials for corneal regeneration.
In: Mozafari, Masoud (ed.): Nanoengineered Biomaterials for Regenerative Medicine : Micro and Nano Technologies. - Amsterdam : Elsevier , 2019 . - pp. 379-415
ISBN 978-0-12-813356-9
DOI: https://doi.org/10.1016/B978-0-12-813355-2.00017-X

Abstract in another language

The cornea is the outer, transparent structure at the front of the human eye. The cor-nea’s unique structure is based on its resident cells and the organization of the cornealextracellular matrix (ECM). The cornea supports the refraction and transmission ofincoming light (Fig. 1A)[1,2]. It also provides mechanical and chemical protectionof the inner eye tissue. In adults, the cornea’s average horizontal diameter is11.5–12.0 mm, which is about 1 mm larger than its vertical diameter. The thicknessis approximately 0.5 mm at the center and gradually increases toward the periphery.The cornea is flat in the periphery and is arched centrally, which creates an asphericoptical system with a specific biomechanical structure[3]. This tissue is avascular,but it relies on blood components coming from tear films and tiny vessels of the facialarteries[4].The cornea comprises five layers (Fig. 1B). From front to back, they are the cor-neal epithelium, the Bowman’s layer, the corneal stroma, the Descemet’s membrane,and the corneal endothelium[5]. Resident cells of these layers include the cornealepithelium, the keratocytes in the stroma, and the corneal endothelial cells(CECs).[6,7]The epithelial layer at the ocular surface of the cornea is a first barrier to the out-side environment and is in contact with the tear film. Such an interface is opticallyimportant for the refraction of the eye. Eventually, two thirds of the total refractivepower will be provided by the interface of the air-tear film and the underlying cornea

Further data

Item Type: Article in a book
Refereed: Yes
Additional notes: Chapter 17
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 20 Jan 2020 10:44
Last Modified: 20 Jan 2020 10:44
URI: https://eref.uni-bayreuth.de/id/eprint/54138