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Nanoscale patterning of surface via DNA directed spider silk assembly

Title data

Molina, Anton ; Scheibel, Thomas ; Humenik, Martin:
Nanoscale patterning of surface via DNA directed spider silk assembly.
In: Biomacromolecules. Vol. 20 (20 November 2018) Issue 1 . - pp. 347-352.
ISSN 1526-4602
DOI: https://doi.org/10.1021/acs.biomac.8b01333

Abstract in another language

Oligonucleotide-spider silk conjugates can be placed on silicon wafers by complementary DNA strands, which are coupled chemically to the surface. Such specific immobilization of spider silk proteins allows the nucleation and guided growth of β-sheet-rich nanofibrils in the presence of phosphate ions on the surface. Adjustment of the concentration of the immobilized conjugate, phosphate concentration and time of the assembly reaction enables control over fibril surface density and length. Furthermore, soft lithography was used to direct the conjugates on predetermined spots with a submicron resolution yielding high contrast surface patterns. This approach, which combines bottom-up and top-down surface structuring, opens up new possibilities in protein fibril based bionanotechnology.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 20 Jan 2020 10:51
Last Modified: 20 Jan 2020 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/54139